Our laboratory has had a long standing interest in protein kinases and signal transduction, and recently has focused on the molecular mechanisms of Alzheimer's Disease and related dementias. We employ a multidisciplinary approach combining the methods of protein purification, molecular cloning, genetic engineering, protein chemistry, and kinetic and biophysical analysis to investigate the cellular mechanisms that lead to dementia, on both a molecular biological and detailed structure/mechanistic level. The research in our laboratory falls into two main projects: